PHARMACOLOGY WITH LAB
Academic Year 2022/2023 - Teacher: FILIPPO CARACIExpected Learning Outcomes
Aim of this course is to provide a specific knowledge of the molecular mechanisms underlying both clinical efficacy and side effects of the psychotropic drugs used for the treatment of psychiatric disorders.The course is designed to enhance the knowledge base of future psychologists in psychopharmacology working in medical settings, private practice, or other settings where the interaction with the psychiatrists is critical to improve patient care and manage patients with neuropsychiatric disorders. According to this aim a laboratory of Psychopharmacology will be planned during the course to evaluate the role of psychometric tests in the evaluation of the clinical efficacy of psychotropic drugs and in particular in the pharmacological treatment of depression, bipolar disorder, ADHD, and mild cognitive impairment.
Course Structure
The course will consist of lectures
A specific section of the course (laboratory of psychopharmacology) will be dedicated to discuss the potential applications of psychometric tests in the evaluation of the clinical efficacy of psychotropic drugs
Learning assessment may also be carried out on line, should the conditions require it.
Required Prerequisites
- Basic knowledge of biology and chemistry
- Good knowledge of the Anatomy of the Central and Peripheral Nervous System
- Good knowledge of Physiology with particular attention to neurophysiology and neurobiology of the main neurotransmitter systems
- Good knowledge
of Psychobiology
- Good knowledge
of Clinical Psychology
Detailed Course Content
The first part of the course will be dedicated to the general principles of pharmacokinetics and pharmacodynamics.
During the second part of the course we will examine the pharmacodynamic and pharmacokinetic profile as well as the therapeutic indications of antidepressants, mood stabilizers, anxiolytics and hypnotics and antipsychotic drugs.
Specific topics will be then analyzed such as the neurobiological basis and pharmacological treatment of addiction, the possible role of psychotropic drugs for the treatment of psychiatric disorders in childhood and adolescence, eating disorders and personality disorders. A specific session will be dedicated to geriatric psychopharmacology focusing on the neurobiological basis and pharmacological treatment of Alzheimer’s disease, Parkinson’s disease and post-stroke depression.
A laboratory of Psychopharmacology will be planned with the aim to examine the role of psychometric tests in the pharmacological treatment of depression, bipolar disorder, ADHD, Mild Cognitive impairment with the discussion of specific clinical cases.
Textbook Information
- Julien RM, Advokat CD, Comaty JE. A Primer of Drug Action. 2012, XII edition, pp. 1-248; pp. 519-621.
- Stahl S. Essential Psychopharmacology. Fourth Edition, Cambridge University Press.
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Neurobiologia e Neurofarmacologia del sistema serotoninergico | Indice Julien RM, Advokat CD, Comaty JE |
| 2 | Neurobiologia e Neurofarmacologia del sistema gabaergico | Indice Julien RM, Advokat CD, Comaty JE |
| 3 | Neurobiologia e Neurofarmacologia del sistema glutammatergico | Indice Julien RM, Advokat CD, Comaty JE |
| 4 | Neurobiologia e Neurofarmacologia del sistema dopaminergico e noradrenergico | Indice Julien RM, Advokat CD, Comaty JE-Dispensa Lezioni |
| 5 | Neurobiologia e Neurofarmacologia del sistema colinergico | Indice Julien RM, Advokat CD, Comaty JE-Dispensa Lezioni |
| 6 | Principi fondamentali di farmacocinetica: assorbimento e distribuzione dei farmaci | Indice Julien RM, Advokat CD, Comaty JE |
| 7 | Principi fondamentali di farmacocinetica:metabolismo dei farmaci | Indice Julien RM, Advokat CD, Comaty JE |
| 8 | Principi fondamentali di farmacocinetica:eliminazione dei farmaci | Indice Julien RM, Advokat CD, Comaty JE |
| 9 | Principi fondamentali di farmacodinamica | Indice Julien RM, Advokat CD, Comaty JE |
| 10 | I recettori metabotropici e ionotropici | Indice Julien RM, Advokat CD, Comaty JE-Dispensa Lezioni |
| 11 | Farmaci antidepressivi IMAO e triciclici | Indice Julien RM, Advokat CD, Comaty JE-Dispensa Lezioni |
| 12 | Farmaci antidepressivi SSRI e SNRI | Indice Julien RM, Advokat CD, Comaty JE-Dispensa Lezioni |
| 13 | Farmaci stabilizzanti del tono dell’umore | Indice Julien RM, Advokat CD, Comaty JE |
| 14 | Farmaci ansiolitici ed ipnoinducenti | Indice Julien RM, Advokat CD, Comaty JE |
| 15 | Farmaci antipsicotici di prima generazione | Indice Julien RM, Advokat CD, Comaty JE |
| 16 | Farmaci antipsicotici di seconda generazione | Indice Julien RM, Advokat CD, Comaty JE |
| 17 | Principali indicazioni terapeutiche dei farmaci psicotropi | Indice Julien RM, Advokat CD, Comaty JE |
| 18 | Basi neurobiologiche e trattamento farmacologico delle diverse forme di dipendenze | Indice Julien RM, Advokat CD, Comaty JE |
| 19 | Ruolo degli psicofarmaci nel trattamento dei disturbi psichici dell’infanzia e dell’adolescenza | Indice Julien RM, Advokat CD, Comaty JE |
| 20 | Ruolo degli psicofarmaci dei disturbi della condotta alimentare e dei disturbi di personalità | Indice Julien RM, Advokat CD, Comaty JE |
| 21 | Possibile uso off-label degli psicofarmaci | Indice Julien RM, Advokat CD, Comaty JE-Dispensa Lezioni |
| 22 | Possibile uso degli psicofarmaci in gravidanza e nel puerperio | Indice Julien RM, Advokat CD, Comaty JE |
| 23 | Psicofarmacologia geriatrica I: basi neurobiologiche e trattamento farmacologico della malattia di Alzheimer | Indice Di Nuovo-Vianello, Deterioramento cognitivo: forme, diagnosi e intervento.MILANO:FrancoAngeli, 2013 |
| 24 | Psicofarmacologia geriatrica II: basi neurobiologiche e trattamento farmacologico della malattia di Parkinson e della depressione post-stroke | Indice Julien RM, Advokat CD, Comaty JE |
| 25 | Laboratorio di farmacologia: psicometria e trattamento farmacologico della depressione maggiore e del disturbo bipolare | Indice Julien RM, Advokat CD, Comaty JE-Dispensa in formato PPT |
| 26 | Laboratorio di Farmacologia : Psicometria e trattamento farmacologico dell’ADHD e del declino cognitivo lieve. | Indice Di Nuovo-Vianello, Deterioramento cognitivo: forme, diagnosi e intervento. MILANO:FrancoAngeli, 2013-Dispensa in formato ppt |
| 27 | Laboratorio di Farmacologia : Psicometria e trattamento farmacologico della schizofrenia | Dispensa in formato ppt/pdf |
| 28 | Laboratorio di Farmacologia : abuso di cannabis e possibile ruolo della valutazione neuropsicologica per la pianificazio ne del trattamento | Julien et al. + Dispensa aggiornata in formato pdf |